Prevalence of osteoporosis in hysterectomised as compared to non-hysterectomized women in 7th decade of life

Background: Osteoporosis is considered as a major public health issue with fragility fractures of the hip, vertebrae and distal radius being the most important consequences. It has been said to be an age-related degenerative process. However, postmenopausal women develop this disease due to age-related bone mineral loss as well as due to declining levels of estrogen in the body following menopause leading to increased risk of fractures. Objectives of this study were to find out the prevalence of osteoporosis in hysterectomised and non-hysterectomised postmenopausal women in 7th decade of life.Methods: Descriptive cross-sectional study done on a total of 66 postmenopausal women who were in their 7th decade of life. They were divided into two groups, one consisting of 36 women who underwent natural menopause and the other group of 30 women who had surgical menopause. The bone mineral density of both the groups was measured using DEXA scan and comparison was done between these study groups.Results: Out of 30 hysterectomised subjects, 24 (80%) were found to be having osteoporosis, 6 (20%) had osteopenia and none had normal BMD. While out of 36 subjects in the non-hysterectomised group, 14 (38.88%) had osteoporosis, 16 (44.44%) had osteopenia and 6 (16.66%) subjects had normal BMD. Significant relation (p-value 0.001) was found on comparison of the study groups. In addition, significant positive correlation was between BMD and BMI whereas negative correlation was seen between BMD and parity.Conclusions: Hysterectomy was found to increase the incidence of osteoporosis. Obesity was found to have protective effect against bone mineral loss while increasing parity had a negative relation with BMD

A Comparison of Students’ Thermal Comfort and Perceived Learning Performance between Two Types of University Halls:Architecture Design Studios and Ordinary Lecture Rooms during the Heating Season

In classrooms, several variables may affect students’ thermal comfort, and hence health, well-being, and learning performance. In particular, the type of learning activity may play a role in students’ thermal comfort. However, most of the previous research has mainly investigated the thermal comfort of students in ordinary classrooms, while less attention has been paid to students’ thermal comfort in classrooms with particular learning activities, such as architecture design studios, where students spend a long time and perform learning activities with high metabolic rates. For this purpose, we compared the thermal comfort and perceived learning performance of students majoring in architecture (n = 173) between two types of university halls, namely, design studios and typical lecture rooms (N = 15). We applied the classroom–comfort–data method, which included collecting physical, physiological, and psychological data from students and classrooms. Data were collected during the heating season (November 2021–January 2022) in a university building in Jordan. We conducted continuous monitoring combined with periodic measures for indoor temperature, relative humidity, mean radiant temperature, and air speed. Questionnaires, focus groups, and observations were also used to collect subjective data from students. The results showed statistically significant differences (Δμ = 3.1 °C, p d = 0.61) in indoor temperature between design studios and lecture rooms. Only 58% of students’ votes were within the ASHRAE 55-2107 recommended comfort zone. In design studios, 53% of students felt warm compared to 58.8% of students who had a cold sensation in lecture rooms. Students perceived themselves as more productive when they felt cooler. Our research’s significance lies in its injunction that there must be a special thermal comfort guide for educational buildings that are adapted to the local environment and functions of the spaces, cooperatively

Consequences of Drug Abuse among Female and Male Population of Karachi: A Statistical Surveyed Approach

Drugs are chemicals. Different drugs, because of their chemical structures, can affect the body in different ways. The most obvious effects of drug abuse which are manifested in the individuals include ill health, sickness and ultimately, death. The social life is also not spared by the hazardous impacts of the problem. Whereas the load at health department is increased, rise in crime rate is also a perilous effect faced by the society related to the growth of abusers in the country. The following study highlights the different effects that can influence male and female drug abusers to get rid of their drug misuse habits. Abusers age, level of awareness about drugs adverse effects, their encounters to health ailments including the life threatening infection HIV, and involvement in crimes were included in the survey which was carried out in Karachi in order to assess the magnitude of this problem

Quasi experimental analysis to evaluate the effects of educational sessions in improvement of Knowledge Practice regarding Food hygiene among women in rural community.

Care Introduction: Food is a vital need for a human being it's a source of energy that provides important ingredients for body growth. According to the European Food Safety Authority food composition affecting 69553 individuals, with the domestic kitchen as a second-most typically reported setting for food contamination. Food handlers (women) play an important role in the incidences of food spoilage. By health education knowledge of food, hygiene can be improved. Methods: Quasi-experimental study design was used in this study by using pre and post-test phase, conducted among women in rural community Ali Raza Abad Lahore, to determine the effectiveness of health education on knowledge and practice of food hygiene in women. The sample size was 60 that calculated by using convenient sampling technique in which those participants selected who were conveniently available to participate in the study. SPSS version 21 statistical software was used for data analysis at 95% of confidence interval and P-value was 0.05 Results: Results showed that the total mean of knowledge before intervention was 15.75 but after intervention, the total mean of knowledge was 27.93 similarly the total mean of practice before the intervention was 16.23 but after interventions mean of practice was 34.95 that showed the significant increase in knowledge and practice of women regarding food hygiene. Conclusions: This study described the effectiveness of health education for knowledge and practice of food hygiene among women in the rural community. The mean knowledge and practice score on food hygiene increased significantly after health education. Keywords- Effectiveness. Health education. Food hygiene. Knowledge. Practice.

Pharmacological Potential of Hippophae rhamnoides L. Nano-Emulsion for Management of Polycystic Ovarian Syndrome in Animals’ Model: In Vitro and In Vivo Studies

The most common female endocrinopathy, polycystic ovarian syndrome (PCOS), generally affects women of childbearing age. Hippophae rhamnoides L. has been traditionally used to improve menstrual cyclicity. Gas chromatography by flame ionization detection analysis showed that it contained various phytoconstituents such as omega-3 fatty acid, phytosterols, palmitic acid, oleic acid, and linoleic acid. H. rhamnoides L. (HR) nano-emulsion was also formulated. HR and its encapsulated nano-emulsion (HRNE) were evaluated for the treatment of PCOS. Thirty-five healthy female adult albino rats were acquired and divided into seven groups (n = 5). Letrozole (1 mg/kg) was used for 5 weeks to induce the disease. To confirm disease (PCOS) induction, the animals were weighed weekly and their vaginal smears were analyzed daily under a microscope. After PCOS induction, animals were treated with metformin, HR, and HRNE with two different doses (0.5/kg and 1 g/kg, p.o.) for 5 weeks. At the end of the treatment, animals were euthanized, and blood was collected for hormonal assessment, lipid profiling, and liver functioning test assessment. Both the ovaries were preserved for histopathology and liver for the purpose of assessment of antioxidant potential. The results revealed that HR and HRNE at both doses improved the hormonal imbalance; follicle-stimulating hormone, estrogen, and progesterone levels are increased, while luteinizing hormone surge and testosterone level are controlled. Insulin sensitivity is improved. Ovarian histopathology showed that normal ovarian echotexture is restored with corpus luteum and mature and developing follicles. HR and HRNE also improved the lipid profile and decreased lipid peroxidation (MDA) with improved antioxidant markers (SOD, CAT, and GSH). Results were statistically analyzed by one-way analysis of variance and were considered significant only if p < 0.05. In conclusion, it can be postulated that H. rhamnoides L. proved effective in the management of PCOS and its nano-emulsion effects were statistically more significant, which might be due to better bioavailability

Response of patients of scabies to Topical Permethrin 5%and Treatment Failure

Objective:               This research was conducted to know response of patients of scabies to Topical permethrin and reasons for its treatment failure.Design:            This was observational type of study.Duration and Time:                              This study was conducted at Dermatology department Lahore General Hospital from 1st July 2017 to 31 december 2017.Method:            Every patient having persistent pruritic rash, aggravated at night and significant family history was included in our study. Written consent from each patient was obtained. Topical Permethrin lotion (5%) was provided to the patient and patients were asked to follow up 2 week after application of Permethrin lotion. On followup Patients were asked about improvement of prior symptoms and response to treatment was assessed. Factors leading to treatment failure were found out in non-respondents.Results:A total of 97 patients were included in our study. In 60(61.85%) patients symptoms had resolved and in 37(38.15%)  patients symptoms did not resolve after application of Permethrin lotion.Out of 37 patients, 17(45.94%) patients told that their close family contacts did not use the lotion, 12( 32.43%) patients did not follow environmental control measures, 5(13.51%) patients did not follow guidelines of applying topical permethrin , 3(8.10%)  patients showed no improvement in symptoms of scabies despite following all measures.Conclusion:Topical Permethrin (5%) is an excellent treatment option for scabies. However treatment of close contacts, environmental measures and Proper technique of Permethrin application is very important for the best results.

Response of patients of scabies to Topical Permethrin 5%and Treatment Failure

Objective:               This research was conducted to know response of patients of scabies to Topical permethrin and reasons for its treatment failure.Design:            This was observational type of study.Duration and Time:                              This study was conducted at Dermatology department Lahore General Hospital from 1st July 2017 to 31 december 2017.Method:            Every patient having persistent pruritic rash, aggravated at night and significant family history was included in our study. Written consent from each patient was obtained. Topical Permethrin lotion (5%) was provided to the patient and patients were asked to follow up 2 week after application of Permethrin lotion. On followup Patients were asked about improvement of prior symptoms and response to treatment was assessed. Factors leading to treatment failure were found out in non-respondents.Results:A total of 97 patients were included in our study. In 60(61.85%) patients symptoms had resolved and in 37(38.15%)  patients symptoms did not resolve after application of Permethrin lotion.Out of 37 patients, 17(45.94%) patients told that their close family contacts did not use the lotion, 12( 32.43%) patients did not follow environmental control measures, 5(13.51%) patients did not follow guidelines of applying topical permethrin , 3(8.10%)  patients showed no improvement in symptoms of scabies despite following all measures.Conclusion:Topical Permethrin (5%) is an excellent treatment option for scabies. However treatment of close contacts, environmental measures and Proper technique of Permethrin application is very important for the best results.

Frequency of Disc Degeneration at Different Levels of Cervical Vertebrae in Adult Patients with Neck Pain on Magnetic Resonance Imaging

Background:Disc degeneration is terminology used for heterogeneous changes affecting the anatomy and physiology of the intervertebral disc. Disc degeneration alters the material properties of the intervertebral disc leading to an unfavorable distribution and transmission of stress to adjacent spinal structures.Objective:The aim of the study was to determine the frequency of disc degeneration at different level of cervical vertebrae in adult patients with neck pain on magnetic resonance imaging.Methodology:In this descriptive study 180 adult patients were included. All patients had been collected from DHQ hospital Gilgit and Ghurki Trust teaching hospital. After informed consent, data were collected through 1.5 tesla GE (closed bore) and 0.35 tesla Hitachi (open bore) MRI machines.Results:Findings show that among 180 adult patients, 136 presented with disc degeneration among which 81 were males and 55 were females. Among 81 males, 63 had disc degeneration at multiple levels while 18 had single disc degeneration. In females 35 patients showed multiple disc degeneration while 20 involved a single disc.Conclusion:It is concluded that disc degeneration is prevalent in males than females. Disc degeneration at multiple levels is higher than single disc degeneration in both genders. Keywords: Disc degeneration, magnetic resonance imaging, intervertebral disc. DOI: 10.7176/JHMN/71-02 Publication date: February 29th 202

Sonographic Evaluation of Cholelithiasis and Its Correlation with Normal/Fatty Liver

Cholelithiasis and Fatty Liver disease are usually observed to coexist. Patients who have gallstones also have Fatty Liver as both of the conditions have same associated risk factors I.e., diabetes mellitus, gender, age, obesity, metabolic syndrome, insulin resistance and high lipids level. Non-Alcoholic Fatty Liver Disease (NAFLD) is also an independent accountable risk factor for the formation of gallstones. We aimed to determine whether there is any correlation between cholelithiasis and fatty liver disease. The study was conducted in Lahore General Hospital, Lahore, Pakistan. The data was collected from March 24,2021 to May 24,2021. Informed consent was taken from all the participants. We did a cohort study comprising the data of 51 patients undergoing physical checkup. The data gathered included age, gender and whether they had normal or fatty liver. Cholelithiasis was diagnosed by confirming the presence of gallstones on abdominal ultrasonography after fasting for approximately 8hrs. it was an observational study for the assessment of correlation between cholelithiasis and fatty liver in the participants. A Total of 51 patients with cholelithiasis were included in our study. Most of the patients were 29 to 70 years of age. The average age of the patients was 42.3 ± 10.1 years. Out of 51 patients, there were 60.8% (P=31) females and 39.2%(P=20) males. Out of 51 cholelithiasis patients there were 31.4%(P=16) had Normal Liver and 68.6%(P=35) were positive with Fatty liver disease. Patients with stone size ranges from 1.90mm to 4.6mm hade Grade 1 Fatty liver as shown in table-5.4, Grade 2 Fatty liver was seen in patients with stone size ranges from 4.5mm to 5.8mm. Fatty liver Grade 3 was not observed in any included patient with cholelithiasis. Results of our study showed that both cholelithiasis and Fatty Liver disease are correlated with each other. Females are at higher risk to be affected by these with diseases. Early detection of Fatty liver in patients of cholelithiasis can help patients to prevent them further complications regarded to fatty liver and cholelithiasis and can play important role in health care of society. Keywords: Non-Alcoholic Fatty Liver Disease, Cholelithiasis, Fatty liver, Ultrasonography. DOI: 10.7176/JHMN/91-07 Publication date:July 31st 202